Orlova group – Pluripotent stem cells for vascular differentiation and disease modeling
Blood vessels are essential for proper functioning of tissues and organs in our body, and vascular dysfunction is associated with many cardiovascular and neurodegenerative diseases. Insight into the interactions between vascular cells and the local microenvironment are therefore key to understanding many different diseases.
Human induced pluripotent stem cells (hiPSCs) derived from patients with genetic vascular disorders can form blood vessel cells and provide human models for disease that can be used to find new therapeutics and strategies for disease prevention.
Read more at https://www.orlovalab.com.
Themes for innovation and Societal Outreach
Key publications
Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Scalable microphysiological system to model three-dimensional blood vessels
Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives
Quantifying Ca2+ signaling and contraction in vascular pericytes and smooth muscle cells
Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
Functionality of Endothelial Cells and Pericytes From Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts
Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device†
All publications
Our team
- Dr. Valeria Orlova (Group Leader)
- Francijna (Lisa) van den Hil (Research technician)
- Dr. Amy Cochrane (Postdoc)
- Dr. Marc Vila Cuenca (Postdoc)
- Mees de Graaf (PhD student)
- Dennis Nahon (PhD student)
- Dhanesh Kasi (PhD student)
- Merve Bulut (PhD student)
- Ulgu Arslan (PhD student)