DNA damage responses and cancer
Organisms and cells deploy various strategies to protect themselves against potential harmful effects of DNA damage resulting from physical or chemical agents either endogenously produced or present in the environment. DNA damage response (DDR) pathways such as cell cycle arrest, DNA repair and apoptosis aim to reduce the chance on DNA damage-induced genetic alterations that may eventually lead to cancer or contribute to ageing.
My research group aims to gather and use mechanistic knowledge on mammalian DDR pathways for the following goals:
- Development of novel (geno)toxicity test systems
- Translating fundamental knowledge on DDR pathways to the clinic
- Biological consequences of low dose ionizing radiation
Key publications
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas
Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2
Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action
Skipping nonsense to maintain function: the paradigm of BRCA2 exon 12
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas
The functional impact of variants of uncertain significance in BRCA2
BRCA2 hypomorphic missense variants confer moderate risks of breast cancer
Xenobiotic metabolism in differentiated human bronchial epithelial cells
The extended ToxTracker assay discriminates between induction of DNA damage, oxidative stress and protein misfolding
Our team
Dr. Harry Vrieling
Principal Investigator / Associate Professor
Maaike P.G. Vreeswijk
Associate professor
Jan J.W.A. Boei
Researcher
Romy L.S. Mesman
Researcher
Dr. Harry Vrieling
Principal Investigator / Associate Professor
Maaike P.G. Vreeswijk
Associate professor
Jan J.W.A. Boei
Researcher
Romy L.S. Mesman
Researcher
Sylvia Gelpke-Vermeulen
Research technician
Annelot P. Wondergem
Research technician