Leids Universitair Medisch Centrum
 

W.B. van den Hout



Vakgebied(en):
  • Cost-effectiveness Analysis
  • Health Technology Assessment
  • Mathematical Disease Modelling
  • Utility theory

Position

Senior Researcher, Econometrician / Health Economist

Curriculum vitae

Wilbert van den Hout graduated in econometrics and in acutarial sciences at the University of Amsterdam in 1991. In 1996 he obtained his PhD at the University of Tilburg, for research concerning a numerical method for analysing Markovian queuing systems. Since then he has been working as a senior researcher in Health Technology Assessment, at the department of Medical Decision Making of the Leiden University Medical Center. The main focus of his work is on conducting and supervising economic evaluations, either alongside clinical trials or using mathematical models. His theoretical reserach deals with methodological aspects of measuring utilities and costs and on disease modelling.

Publications

  • Van den Hout WB, Bremander A, Vliet Vlieland TP. Recommendations for economic evaluations of non-pharmacological arthritis care: results from the CARE VI meeting 2010.  Musculoskeletal Care. 2011; 9:120-123.
  • Van der Meer V, Van den Hout WB, Bakker MJ, Rabe KF, Sterk PJ, Assendelft WJ, Kievit J, Sont JK; on behalf of the SMASHING (Self-Management in Asthma Supported by Hospitals, ICT, Nurses and General Practitioners) Study Group. Cost-Effectiveness of Internet-Based Self-Management Compared with Usual Care in Asthma.  PLoS One. 2011; 6:e27108. Epub 2011 Nov 11.
  • Van den Akker ME, Arts MP, Van den Hout WB, Brand R, Koes BW, Peul WC. Tubular diskectomy vs conventional microdiskectomy for the treatment of lumbar disk-related sciatica: cost utility analysis alongside a double-blind randomized controlled trial.  Neurosurgery. 2011; 69:829-835.
  • Van der Weele GM, de Waal MW, Van den Hout WB, Van der Mast RC, de Craen AJ, Assendelft WJ, Gussekloo J. Yield and costs of direct and stepped screening for depressive symptoms in subjects aged 75 years and over in general practice.  Int J Geriatr Psychiatry. 2011; 26:229-238.
  • Van den Hout WB. The value of productivity: human-capital versus friction-cost method.  Ann Rheum Dis. 2010; 69 Suppl 1:i89-91.
  • Van der Meer V, Bakker MJ, Van den Hout WB, Rabe KF, Sterk PJ, Kievit J, Assendelft WJJ, Sont JK. Zelfmanagement van astma via internet. Ned Tijdschr Geneeskd 2010; 154: 403-409.
  • Van der Meer V, Bakker MJ, Van den Hout WB, Rabe KF, Sterk PJ, Kievit J, Assendelft WJ, Sont JK; SMASHING Study Group. Internet-based self-management plus education compared with usual care in asthma: a randomized trial.  Ann Intern Med. 2009; 151:110-120.
  • Meijer JA, le Cessie S, Van den Hout WB, Kievit J, Schoones JW, Romijn JA, Smit JW. Calcitonin and carcinoembryonic antigen doubling times as prognostic factors in medullary thyroid carcinoma: a structured meta-analysis.  Clin Endocrinol (Oxf). 2010; 72:534-542.
  • Van den Hout WB, Goekoop-Ruiterman YP, Allaart CF, De Vries-Bouwstra JK, Hazes JMM, Kerstens PJSM, Van Zeben D, Hulsmans HMJ, De Jonge-Bok JM, De Sonnaville PBJ, Dijkmans BAC, Breedveld FC. Cost-utility analysis of treatment strategies in patients with recent onset rheumatoid arthritis.  Arthritis Rheum. 2009; 61:291-299.
  • Van den Hout WB. Deficiencies in current evaluations of the cost-effectiveness of biologic agents for RA.  Nat Clin Pract Rheumatol. 2009; 5:78-79.
  • Vliet Vlieland TPM, De Buck PDM, Van den Hout WB. Vocational rehabilitation programs for individuals with chronic arthritis.  Current Opinion in Rheumatology 2009; 21:183–188.
  • Verweij AMFP, Van der Wel MW, Mileman PA, Den Dekker J, Van den Hout WB. Het effect van de klachtkans op een behandelbeslissing: een exploratief onderzoek onder vierdejaarsstudenten tandheelkunde.  Ned Tijdschr. Tandheelkd. 2009; 116: 125-129.
  • Mileman PA, Van den Hout WB. Improving treatment decisions from radiographs: effect of a decision aid.  Int J of Computer Assisted Radiology and Surgery 2009; 4:367-373.
  • Mileman PA, Van den Hout WB. Evidence-based diagnosis and clinical decision making.  Dentomaxillofac.Radiol. 2009; 38:1-10.
  • Van den Hout WB. Dominance.  In Kattan MW, ed.  Encyclopedia of Medical Decision Making.  Thousand Oaks, CA: Sage Publications, 2009: 413-415.
  • Van den Hout WB. Economics, Health economics.  In Kattan MW, ed.  Encyclopedia of Medical Decision Making.  Thousand Oaks, CA: Sage Publications, 2009: 423-427.
  • Van den Hout WB. Markov Processes.  In Kattan MW, ed.  Encyclopedia of Medical Decision Making.  Thousand Oaks, CA: Sage Publications, 2009: 715-721.
  • Vliet Vlieland TPM, Van den Hout WB, De Buck PDM. Can anti-TNF agents protect against rheumatoid arthritis-associated work disability? Int. J. Clin. Rheumatol. 2009; 4: 523-531.
  • Van den Hout WB, Peul WC, Koes BW, Brand R, Kievit J, Thomeer RT. Prolonged conservative care versus early surgery in patients with sciatica from lumbar disc herniation: cost utility analysis alongside a randomised controlled trial.  BMJ 2008; 336:1351-1354.
  • Peul WC, Van den Hout WB, Brand R, Thomeer RT, Koes BW. Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial.  BMJ 2008; 336:1355-1358.
  • Mileman PA, Van den Hout WB. An evaluation by teachers of a decision aid for viewing bitewing radiographs.  Dentomaxillofac.Radiol. 2008; 37:425-432.
  • Ten Wolde GB, Dijkstra A, Van Empelen P, Van den Hout W, Neven AK, Zitman F. Long-term effectiveness of computer-generated tailored patient education on benzodiazepines: a randomized controlled trial.  Addiction 2008; 103:662-670.
  • Klop WM, Boermans PP, Ferrier MB, Van den Hout WB, Stiggelbout AM, Frijns JH. Clinical Relevance of Quality of Life Outcome in Cochlear Implantation in Postlingually Deafened Adults.  Otol Neurotol. 2008; 29:615-621.
  • Van den Hout WB, De Buck PDM, Vliet Vlieland TPM. Cost-utility analysis of a multidisciplinary job retention vocational rehabilitation programme in patients with chronic arthritis at risk of job loss.  Arthritis Rheum. 2007; 57:778-786.
  • Peul WC, Van Houwelingen HC, Van den Hout WB, Brand R, Eekhof JA, Tans JT, Thomeer RT, Koes BW. Surgery versus Prolonged Conservative Treatment for Sciatica.  N.Engl.J.Med. 2007; 356:2245-2256.
  • Van den Hout WB. Doelmatigheid en Ziektelast. TAnews oktober 2007:6-8.
  • Nielsen M, Hes FJ, Vasen HF, Van den Hout WB. Cost-utility analysis of genetic screening in families of patients with germline MUTYH mutations.  BMC Med.Genet. 2007; 8:42.
  • Vincken PW, Ter Braak AP, Van Erkel AR, Coerkamp EG, De Rooy TP, De Lange S, Mallens WM, Coene LN, Bloem RM, Van Luijt PA, Van den Hout WB, Van Houwelingen HC, Bloem JL. MR Imaging: Effectiveness and Costs at Triage of Patients with Nonacute Knee Symptoms.  Radiology 2007; 242:85-93.
  • Kolkman W, Van de Put MAJ, Van den Hout WB, Trimbos JBMZ, Jansen FW. The implementation of the laparoscopic simulator in gynecological residency curriculum.
     Surgical Endoscopy 2007; 21:1363-1368.
  • Peul WC, Van Houwelingen HC, Van den Hout WB, Brand R, Eekhof JAH, Tans JTJ, Thomeer RTWM, Koes BW. Vroeg opereren of langer afwachten voor het lumbosacraal radiculair syndroom: een gerandomiseerd onderzoek.  Ned.Tijdschr.Geneeskd. 2007; 151:2512-2523.
  • Mileman PA, Van den Hout WB. Evidence-based diagnostiek en klinische besluitvorming.  Ned.Tijdschr.Tandheelkunde 2007; 114:187-194.
  • Heemskerk R. Kostbare tijd.  Cicero 24 maart 2007:4-5. (Interview over economische evaluaties en QALYs)
  • Van den Hout WB. EuroQol data in terminally-ill cancer patients.  Poster presented at the annual meeting of the society for Medical Decision making 2007.
  • Van den Hout WB, Kramer GWPM, Noordijk EM, Leer JWH. Cost-utility analysis of short- versus long-course palliative radiotherapy in patients with non-small-cell lung cancer.  J.Natl.Cancer Inst. 2006; 98:1786-1794.
  • Van den Hout WB. EuroQol data in terminally-ill cancer patients. Poster presented at the 10th Biennial European Meeting of the Society for Medical Decision Making, 11-13 June 2006, Birmingham, United Kingdom.
  • De Buck PDM, De Bock GH, Van Dijk F, Van den Hout WB, Vandenbroucke JP, Vliet Vlieland TPM. Sick leave as a predictor of job loss in patients with chronic arthritis.  Int.Arch.Occup.Environ.Health 2006; 80:160-170.
  • Groothuis-Oudshoorn CGM, Chorus AMJ, Taeke van Beekum W, Detmar SB, Van den Hout WB. Modelling and estimation of valuations for the Dutch London Handicap Scale.
     J.Health Econ. 2006; 25:1119-1138.
  • Van Osch SMC, Van den Hout WB, Stiggelbout AM. Exploring the reference point in prospect theory: gambles for length of life.  Med.Decis.Making 2006; 26:338-346.
  • Van den Hout WB, De Jong Z, Munneke M, Hazes JM, Breedveld FC, Vliet Vlieland TPM. Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis.  Arthritis Rheum. 2005; 53:39-47.
  • Van den Hout WB, Vermeulen HM, Rozing PM, Vliet Vlieland TPM. Impact of adhesive capsulitis and economic evaluation of high-grade and low-grade mobilisation techniques.
     Australian Journal of Physiotherapy 2005; 51:141-149.
  • Van den Brink M, Van den Hout WB, Stiggelbout AM, Putter H, Van de Velde CJ, Kievit J. Self-reports of health care utilization: diary or questionnaire?  Int.J.Technol.Assess.Health Care 2005; 21:298-304.
  • Teng YK, Verburg RJ, Sont JK, Van den Hout WB, Breedveld FC, Van Laar JM. Long-term followup of health status in patients with severe rheumatoid arthritis after high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation.  Arthritis Rheum.2005; 52:2272-2276.
  • Van den Brink M, Van den Hout WB, Kievit J, Marijnen CA, Putter H, Van de Velde CJ, Stiggelbout AM. The impact of diagnosis and treatment of rectal cancer on paid and unpaid labour.  Dis.Colon.Rectum 2005; 48:1875-1882.
  • Van den Brink M, Van den Hout WB, Stiggelbout AM, Kievit J, Van de Velde CJ. What you may learn from the Dutch experience.  J.Clin.Oncol. 2005; 23:3632-3633.
  • De Buck PDM, le Cessie S, Van den Hout WB, Peeters AJ, Ronday HK, Westedt ML, Breedveld FC, Vliet Vlieland TPM. Randomized comparison of a multidisciplinary job-retention vocational rehabilitation program with usual outpatient care in patients with chronic arthritis at risk for job loss.  Arthritis Care and Research 2005; 53:682-690.
  • Kramer GW, Wanders SL, Noordijk EM, Vonk EJ, Van Houwelingen HC, Van den Hout WB, Geskus RB, Scholten M, Leer JW. Results of the Dutch National study of the palliative effect of irradiation using two different treatment schemes for non-small-cell lung cancer.  J.Clin.Oncol. 2005; 23:2962-2970.
  • Van Hilten JA, Van de Watering LMG, Van Bockel JH, Van de Velde CJH, Kievit J, Brand R, Van den Hout WB, Geelkerken RH, Roumen RMH, Wesselink RMJ, Koopman-van Gemert AWMM, Koning J, Brand A. De effecten van leukocytenverwijdering uit rodebloedcelconcentraten door filtratie: Een gerandomiseerde studie bij patiŽnten die een grote chirurgische ingreep ondergaan.  Ned.Tijdschr.Hematologie 2005; 2:140-147.
  • Peul WC, Van Houwelingen HC, Van den Hout WB, Brand R, Eekhof JA, Tans JT, Thomeer RT, Koes BW. Prolonged conservative treatment or 'early' surgery in sciatica caused by a lumbar disc herniation: rationale and design of a randomized trial [ISRCT 26872154].  BMC Musculoskelet Disord. 2005; 6:8.
  • Van den Brink M, Stiggelbout AM, Van den Hout WB, Kievit J, Klein Kranenbarg E, Marijnen CAM, Nagtegaal ID, Rutten HJ, Wiggers T, Van de Velde CJH. Clinical nature and prognosis of locally recurrent cancer after total mesorectal excision with or without preoperative radiotherapy.  J.Clin.Oncol. 2004; 22:3958-3964.
  • Van Osch SMC, Wakker PP, Van den Hout WB, Stiggelbout AM. Correcting biases in standard gamble and time tradeoff utilities.  Med.Decis.Making 2004; 24:511-517.
  • Van den Hout WB. The GAME estimate of reduced life expectancy.  Med.Decis.Making 2004; 24:80-88. Worked out example
  • Van Hilten JA, Van de Watering LMG, Van Bockel JH, Van de Velde CJH, Kievit J, Brand R, Van den Hout WB, Geelkerken RH, Roumen RMH, Wesselink RMJ, Koopman-van Gemert AWMM, Koning J, Brand A, for the TACTICS group. Effects of filtered leukocyte -depleted- red cell transfusions in major surgery: A randomised controlled trial.  BMJ 2004; 328:1281-1284.
  • Van den Brink M, Van den Hout WB, Stiggelbout AM, Klein Kranenbarg E, Marijnen CAM, Van de Velde CJH, Kievit J, for the Dutch Colorectal Cancer Group. Cost-utility analysis of preoperative radiotherapy in patients with rectal cancer undergoing total mesorectal excision.  J.Clin.Oncol. 2004; 22:244-253.
  • Van den Brink M, Van den Hout WB, Stiggelbout AM, Van de Velde CJH, Kievit J. Cost measurement in economic evaluations of health care: Whom to ask?  Medical Care 2004; 42:740-746.
  • Mileman PA, Van den Hout WB, Sanderink GC. Looking for caries...? Teachers evaluate a program to improve caries diagnosis from radiographs.
     Eur.J.Dent.Educ. 2004; 8:35-42.
  • Mileman PA, Van den Hout WB. Preferences for oral health states: effect on prescribing periapical radiographs.  Dentomaxillofac.Radiol.2003; 32:401-407.
  • Van den Hout WB, Smits MA, Deng MC, Hummel M, Schoendube F, Scheld HH, Persijn GG, Laufer G, on behalf of the Comparative Outcome and Clinical Profiles in Transplantation (COCPIT) Study Group and on behalf of the Eurotransplant heart transplant programs. The Heart-Allocation Simulation model: a tool for comparison of transplantation allocation  policies.  Transplantation 2003; 76:1492-1497.
  • Van den Hout WB. The area under an ROC curve with limited information.  Med.Decis.Making 2003; 23:160-166.
  • Van den Hout WB, Van der Linden YM, Steenland E, Wiggenraad RGJ, Kievit J, De Haes H, Leer JW. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost-utility analysis based on a randomized trial.  J.Natl.Cancer Inst. 2003; 95:222-229.
  • Mileman PA, Van den Hout WB, Sanderink GCH. Randomized controlled trial of a computer-assisted learning program to improve caries detection from bitewing radiographs.  Dentomaxillofac.Radiol. 2003; 32:116-123.
  • Van den Hout WB, Tijhuis GJ, Hazes JM, Breedveld FC, Vliet Vlieland TPM. Cost effectiveness and cost utility analysis of multidisciplinary care in patients with rheumatoid arthritis: a randomised comparison of clinical nurse specialist care, inpatient team care, and day patient team care.  Ann.Rheum.Dis. 2003; 62:308-315.
  • Van der Linden YM, Steenland E, Post WJ, Van den Hout WB, De Haes JCJM, Leer JWH. Eenmalige bestraling van pijnlijke botmetastasen even effectief als meervoudige bestraling. Uitkomsten van de 'Nederlandse botmetastasenstudie'. Ned.Tijdschr.Geneeskunde 2002; 146:1645-1650.
  • Tijhuis GJ, Zwinderman AH, Hazes JM, Van den Hout WB, Breedveld FC, Vliet Vlieland TPM. A randomized comparison of care provided by a clinical nurse specialist, an inpatient team, and a day patient team in rheumatoid arthritis.  Arthritis Rheum.2002; 47:525-531.
  • Post PN, Kievit J, Van Baalen JM, Van den Hout WB, Van Bockel JH. Routine duplex surveillance does not improve the outcome after carotid endarterectomy: a decision and cost utility analysis.  Stroke 2002; 33:749-755.
  • Mileman PA, Van den Hout WB. Comparing the accuracy of Dutch dentists and dental students in the radiographic diagnosis of dentinal caries.  Dentomaxillofac.Radiol. 2002; 31:7-14.
  • Van den Hout WB, Van den Brink M, Stiggelbout AM, Van de Velde CJ, Kievit J. Cost-effectiveness analysis of colorectal cancer treatments.  Eur.J.Cancer 2002; 38:953-963.
  • Van Erkel AR, Van den Hout WB, Pattynama PM. International differences in health care costs in Europe and the United States: Do these affect the cost-effectiveness of diagnostic strategies for pulmonary embolism?  Eur.Radiol. 1999; 9:1926-1931
  • Steenland E, Leer JW, Van Houwelingen H, Post WJ, Van den Hout WB, Kievit J, De Haes H, Martijn H, Oei B, Vonk E, Van der Steen-Banasik E, Wiggenraad RG, Hoogenhout J, Warlam-Rodenhuis C, Van Tienhoven G, Wanders R, Pomp J, Van Reijn M, Van Mierlo I, Rutten E. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study.  Radiother.Oncol. 1999; 52:101-109.  
  • Van den Hout WB. The Power-Series Algorithm: A numerical approach to Markov Processes, Ph.D. thesis, Tilburg University, 1996. ISBN 90-5668-0-011-0.

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CONTACT
W.B. van den Hout


econometrist / onderzoeker


Leids Universitair Medisch Centrum
Gebouw 1, Kamer J10-89

Postzone J10-S
Postbus 9600
2300 RC Leiden

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Tel: 071 5264577