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dr. B.T. (Bas) Heijmans

Bas Heijmans (1972) studies the role of genomic variation in human disease and ageing. His recent focus is on how the prenatal environment can induce persistent changes in the human epigenome and how these changes may contribute to metabolic disease. This topic fits in his broader research interest to use genome-scale genetic, epigenetic, expression and other molecular data in studying human cardiometabolic disease and ageing. He was trained as a (molecular) biologist and in his human studies he combines the application of medium/high-throughput laboratory techniques with data analysis in the setting of molecular epidemiology.

Publications in Pubmed and Google Scholar.

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Vakgebied(en):

Epigenomics
Genetics
Metabonomics

Epigenomic technologies for DNA methylation detection
Selected study populations
Selected recent publications

Epigenomic technologies for DNA methylation detection

Mass spectrometry (Epityper, Sequenom)
Chips (450k methylation beadchip, Illumina)
High-throughput bisulfite sequencing (RRBS)

Selected study populations

Leiden Longevity Study
Hunger Winter Families Study (Bertie Lumey, Columbia University)
Netherlands Twin Register (Dorret Boomsma, Vrije Universiteit)
Danish Twin Register (Kaare Christensen, Univ. Southern Denmark)
PROSPER (Wouter Jukema, LUMC)
CAREMA (Edith Feskens, Wageningen University)

Selected recent publications

Heijmans BT, Mill J. The seven plagues of epigenetic epidemiology. Int J Epidemiol 2012; 41:74-8.

Beekman M, Nederstigt C, Suchiman HED, Kremer D, Van der Breggen R, Lakenberg N, Ghidey Alemayehu W, de Craen AJ, Westendorp RG, Boomsma DI, De Geus EJC, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. GWAS-identified disease risk alleles do not compromise human longevity. PNAS 2010; 107:18046-9.
Talens RP, Boomsma DI, Tobi EW, Kremer D, Jukema JW, Willemsen G, Putter H, Slagboom PE, Heijmans BT. Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J 2010; 24: 3135-44.
Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE, Heijmans BT. Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One 2009; 4: e7845.
Heijmans BT, Tobi EW, Lumey LH, Slagboom PE. The epigenome: archive of the prenatal environment. Epigenetics 2009; 4: 526-31.
Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE, Heijmans BT. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009; 18: 4046-53.
Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE, Lumey LH. Persistent epigenetic differences associated with prenatal exposure to famine in humans. PNAS 2008; 105: 17046-9.
Heijmans BT, Kremer D, Tobi EW, Boomsma DI, Slagboom PE. Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet 2007; 16: 547-54.
Heijmans BT, Beekman M, Houwing-Duistermaat JJ, Cobain MR, Powell J, Blauw GJ, van der Ouderaa F, Westendorp RG, Slagboom PE. Lipoprotein particle profiles mark familial and sporadic human longevity. PLoS Med 2006; 3: e495.