Research programs

MASH

MASH is an acronym for Mood- Anxiety and Somatoform Disorders and the Hypothalamic Pituitary Adrenal (HPA)-axis. This project, partly funded by ZonMW, focuses on translational research with an accent on the role of the HPA-axis in MAS disorders. Projects include the effects of polymorphisms of the glucocorticoid receptor on cell functions and the role of disregulation of the HPA-axis in psychopathology. Collaborating parties are the department of medical pharmacology and the Central Clinical Chemical Laboratory.

NESDA

The Netherlands Study on Depression and Anxiety (NESDA) is a national cohort-study of 2981 patients designed to investigate the course of depression and anxiety disorders over a period of eight years. NESDA is a cooperative project of several universities (the departments of psychiatry, primary care and clinical psychology of the Leiden University Medical Center / Leiden University, VU medical center / VU University Amsterdam and  the University of Groningen / University Medical Center Groningen), the researchgroups IQ (Scientific Institue for Quality of Healthcare), NIVEL and the  Trimbos-institute, mental health care institutions and clientorganisations. The first assessments took place in 2004. The final asseesments are scheduled for 2012-1014. NESDA is funded by ZonMW. For more information:  www.nesda.nl

NOCDA

The Netherlands OCD Association (NOCDA) is a consortium of University Medical Centers including LUMC and mental health organisations that aims to investigate the long term course of obsessive-compulsive disorders. For more information:  http://nocda.amstad.nl

NESDO

The aim of the Netherlands Study on Depression in Old Age (NESDO) is to investigate the course of depression in patients of over 60 years of age. 450 patients and 150 healthy controls are included. NESDO is closely linked to NESDA, which makes extrapolation of findings possible. The NESDO consortium consists of the departments of psychiatry of The Leiden University Medical Center, VU Medical Center, University Medical Center Groningen, University Medical Center St. Radboud and ‘Nederlands Kenniscentrum Ouderenpsychiatrie’. For more information:  http://nesdo.amstad.nl.

PROMODE

PROactive Management Of Depression in the Elderly (PROMODE) is a large scale study in collaboration with the department of Public Health and Primary Care. The aim of this study is to investigate the effect of screening on depressive symptoms in patients of 75 years and older in primary care, followed by a psychological intervention in terms of effectiveness and cost-efficiency

Psychopathology in Huntington’s disease

In collaboration with the departments of neurology and clinical genetics, the department of psychiatry has built a cohort of Huntington-gene mutation carriers and non-carriers in order to investigate the occurrence and course of mood-, anxiety- and somatoform disorders in Huntington patients in relation to HPA-axis and immune system functioning.

COROM

The ROM Research Center (Dutch: Centrum voor Onderzoek ROM; COROM) aims to initiate and coordinate research projects that use data derived from Routine Outcome Monitoring (ROM) in secondary care psychiatric patients with MAS disorders. ROM is primary used by clinicians to monitor the progress of treatment and to give feedback to the patient. In addition to the clinical use of ROM, data can be used for research purposes. COROM focuses on several topics: 1) Psychometric research: evaluation of questionnaires and development of new questionnaires; 2) Implementation-research; 3) Benchmarking; 4) Outcomes research; 5) Medical decision-making research; 6) Add-on research, eg. effectiveness research on psychotherapy or adding biological parameters or DNA. The MASHBANK is an example of biological add-on research.

Table of instruments

Reglement PAREL

COROM nieuwsbrief 

LIAIROM

The Leiden Institute for the Advancement and Integration of ROM has been founded to facilitate ROM-related research across different mental health organizations. Since ROM has gained in popularity over the recent years, several mental health organizations have adapted the Leiden ROM system. However, scientific research purposes have not been first priority in these developments. Liairom aims to increase comparability of ROM data between different organizations to improve research possibilities.

 

 

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