Publications

2012

•  A Novel 'Gene Insertion/Marker Out' (GIMO) Method for Transgene Expression and Gene Complementation in Rodent Malaria Parasites. Lin JW, Annoura T, Sajid M, Chevalley-Maurel S, Ramesar J, Klop O, Franke-Fayard BM, Janse CJ, Khan SM. 2012; PLoS One. 2011;6(12):e29289.
•  Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo. Fonager J, Pasini EM, Braks JA, Klop O, Ramesar J, Remarque EJ, Vroegrijk IO, van Duinen SG, Thomas AW, Khan SM, Mann M, Kocken CH, Janse CJ, Franke-Fayard BM. 2011; J Exp Med. 2011 Dec 19.

2011

•  Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver. Douradinha B, van Dijk M, van Gemert GJ, Khan SM, Janse CJ, Waters AP, Sauerwein RW, Luty AJ, Silva-Santos B, Mota MM, Epiphanio S. 2011; J Immune Based Ther Vaccines. 17;9(1):6.
•  Experimentally controlled down regulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Laurentino EC, Taylor S, Mair GR, Lasonder E, Bartfai R, Stunnenberg HG, Kroeze H, Ramesar J, Franke-Fayard B, Khan SM, Janse CJ, Waters AP. Cell Microbiol. 2011; 13:1956-74. 
•  CCR4-Associated Factor 1 Coordinates the Expression of Plasmodium falciparum Egress and Invasion Proteins. Balu B, Maher SP, Pance A, Chauhan C, Naumov AV, Andrews RM, Ellis PD, Khan SM, Lin JW, Janse CJ, Rayner JC, Adams JH. Eukaryot Cell. 2011; 10(9):1257-63.
•  The novel putative transporter NPT1 plays a critical role in early stages of Plasmodium berghei sexual development. Boisson B, Lacroix C, Bischoff E, Gueirard P, Bargieri DY, Franke-Fayard B, Janse CJ, Ménard R, Baldacci P. Mol Microbiol. 2011; 81(5):1343-57.
•  Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Wykes MN, Kay JG, Manderson A, Liu XQ, Brown DL, Richard DJ, Wipasa J, Jiang SH, Jones MK, Janse CJ, Waters AP, Pierce SK, Miller LH, Stow JL, Good MF. Proc Natl Acad Sci U S A. 2011; 108(27):11205-10.
•  Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio. Gomes-Santos CS, Braks J, Prudêncio M, Carret C, Gomes AR, Pain A, Feltwell T, Khan S, Waters A, Janse C, Mair GR, Mota MM. PLoS Pathog. 2011; 7(5):e1002046..
•  Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host. Douradinha B, Augustijn KD, Moore SG, Ramesar J, Mota MM, Waters AP, Janse CJ, Thompson J. Malar J. 2011; 10(1):71.
•  Aminoindoles: a Novel Scaffold with Potent Activity against Plasmodium falciparum. Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Santos Martínez M, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Antimicrob Agents Chemother. 2011; 55(6):2612-222
•  Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites.
  Fonager J, Franke-Fayard BM, Adams JH, Ramesar J, Klop O, Khan SM, Janse CJ, Waters AP. BMC Genomics. 2011; 12(1):155.
•  Has the time come for us to complement our malaria parasites? Goldberg DE, Janse CJ, Cowman AF, Waters AP.Trends Parasitol. 2011; 27(1):1-2.
•  A genotype and phenotype database of genetically modified malaria-parasites. Janse CJ, Kroeze H, van Wigcheren A, Mededovic S, Fonager J, Franke-Fayard B, Waters AP, Khan SM. Trends Parasitol. 2011; 27(1):31-9.

2010

•  Removal of heterologous sequences from Plasmodium falciparum mutants uing FLPe-recombinase. van Schaijk BC, Vos MW, Janse CJ, Sauerwein RW, Khan SM. PLoS One. 2010; 5(11):e15121.
•  Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria? Franke-Fayard B, Fonager J, Braks A, Khan SM, Janse CJ. PLoS Pathog. 2010; 6(9). pii: e1001032.
•  Development of the malaria parasite in the skin of the mammalian host. Gueirard P, Tavares J, Thiberge S, Bernex F, Ishino T, Milon G, Franke-Fayard B, Janse CJ, Ménard R, Amino R. Proc Natl Acad Sci U S A. 2010; 107(43):18640-5. 
•  Novel inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Bir Sidhu A, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Krespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. J Biol Chem. 2010; 285(43):33054-64. 
•  Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito. Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodriguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE. J Biol Chem. 2010
•  Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development. Daher W, Pierrot C, Kalamou H, Pinder JC, Margos G, Dive D, Franke-Fayard B, Janse CJ, Khalife J. J Biol Chem. 2010, 285(26):20180-91.
•  Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility. Dijk MR van, BSchaijk BCL van, Khan SM, Dooren MW van, Ramesar J, Kaczanowski S, Gemert GJ van, Kroeze H, Stunnenberg HG, Eling WM, Sauerwein RW, Waters AP, Janse CJ. Plos Pathogens. 2010; 6(4):e1000853.
•  Functional Identification of the Plasmodium Centromere and generation of a Plasmodium Artificial Chromosome. Iwanaga S, Khan SM, Kaneko I, Christodoulou Z, Newbold C, Yuda M, Janse CJ, Waters AP. Cell Host Microbe. 2010; 7(3):245-255
•  Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. Mair GR, Lasonder E, Garver LS, Franke-Fayard BM, Carret CK, Wiegant JC, Dirks RW, Dimopoulos G, Janse CJ, Waters AP. PLoS Pathog. 2010;6(2):e1000767.
•  Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. Spaccapelo R, Janse CJ, Caterbi S, Franke-Fayard B, Bonilla JA, Syphard LM, Di Cristina M, Dottorini T, Savarino A, Cassone A, Bistoni F, Waters AP, Dame JB, Crisanti A. Am J Pathol. 2010;176(1):205-17.