Publications

2010

•  Novel inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
  Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Bir Sidhu A, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Krespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. J Biol Chem. 2010 Aug 11.
•  Has the time come for us to complement our malaria parasites?
  Goldberg DE, Janse CJ, Cowman AF, Waters AP.Trends Parasitol. 2010 Jul 26.
•  A genotype and phenotype database of genetically modified malaria-parasites.
  Janse CJ, Kroeze H, van Wigcheren A, Mededovic S, Fonager J, Franke-Fayard B, Waters AP, Khan SM. Trends Parasitol. 2010 Jul 19.
•  Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.
  Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodriguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE. J Biol Chem. 2010 Jun 23. [Epub ahead of print]
•  Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development. Daher W, Pierrot C, Kalamou H, Pinder JC, Margos G, Dive D, Franke-Fayard B, Janse CJ, Khalife J. J Biol Chem. 2010, 285(26):20180-91.
   Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility. Dijk MR van, BSchaijk BCL van, Khan SM, Dooren MW van, Ramesar J, Kaczanowski S, Gemert GJ van, Kroeze H, Stunnenberg HG, Eling WM, Sauerwein RW, Waters AP, Janse CJ. Plos Pathogens. 2010 Apr 8;6(4):e1000853.
•  Functional Identification of the Plasmodium Centromere and
• Generation of a Plasmodium Artificial Chromosome. Iwanaga S, Khan SM, Kaneko I, Christodoulou Z, Newbold C, Yuda M, Janse CJ, Waters AP. Cell Host Microbe. 2010 Mar 18;7(3):245-255
•  Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. Mair GR, Lasonder E, Garver LS, Franke-Fayard BM, Carret CK, Wiegant JC, Dirks RW, Dimopoulos G, Janse CJ, Waters AP. PLoS Pathog. 2010;6(2):e1000767.
•  Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. Spaccapelo R, Janse CJ, Caterbi S, Franke-Fayard B, Bonilla JA, Syphard LM, Di Cristina M, Dottorini T, Savarino A, Cassone A, Bistoni F, Waters AP, Dame JB, Crisanti A. Am J Pathol. 2010;176(1):205-17.

2009 

•  Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging. Ploemen IHJ, Prudêncio M, Douradinha BG, Ramesar J, Fonager J, van Gemert GJ, Luty AJF, Hermsen CC, Sauerwein RW, Baptista FG, Mota MM, Waters AP, Que I, Lowik CWGM, Khan SM, Janse CJ, Franke-Fayard BMD. PLoS ONE 2009 4(11): e7881.
•  The crystal structures of macrophage migration inhibition factor (MIF) from Plasmodium falciparum and Plasmodium berghei. Dobson SE, Augustijn KD, Brannigan JA, Schnick C, Janse CJ, Dodson EJ, Waters AP, Wilkinson AJ. Protein Sci. 2009; 18(12):2578-91.
•  A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. Moon RW, Taylor CJ, Bex C, Schepers R, Goulding D, Janse CJ, Waters AP, Baker DA, Billker O. PLoS Pathog. 2009 Sep;5(9):e1000599.
•  Going live: A comparative analysis of the suitability of the RFP derivatives RedStar, mCherry and tdTomato for intravital and in vitro live imaging of Plasmodium parasites. Graewe S, Retzlaff S, Struck N, Janse CJ, Heussler VT. Biotechnol J. 2009;4(6):895-902.
•  Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Ponzi M, Sidén-Kiamos I, Bertuccini L, Currà C, Kroeze H, Camarda G, Pace T, Franke-Fayard B, Laurentino EC, Louis C, Waters AP, Janse CJ, Alano P. Cell Microbiol. 2009 11(8):1272-88.
•  LISP1 is important for the egress of Plasmodium berghei parasites from liver cells. Ishino T, Boisson B, Orito Y, Lacroix C, Bischoff E, Loussert C, Janse C, Ménard R, Yuda M, Baldacci P. Cell Microbiol. 2009 11(9):1329-39.
•  Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites. Tufet-Bayona M, Janse CJ, Khan SM, Waters AP, Sinden RE, Franke-Fayard B. Mol Biochem Parasitol. 2009;166(1):22-31.
•  Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Baum J, Papenfuss AT, Mair GR, Janse CJ, Vlachou D, Waters AP, Cowman AF, Crabb BS, de Koning-Ward TF. Nucleic Acids Res. 2009;37(11):3788-98.
•  The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. Vega-Rodríguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodríguez-Orengo JF, Jacobs-Lorena M, Serrano AE. PLoS Pathog. 2009, 5(2):e1000302.
•  Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Yuda M, Iwanaga S, Shigenobu S, Mair GR, Janse CJ, Waters AP, Kato T, Kaneko I. Mol Microbiol. 2009 71:1402-14
•  The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Cell Host Microbe. 2008 4:567-78.
•  Alteration of the Parasite Plasma Membrane and the Parasitophorous Vacuole Membrane during Exo-Erythrocytic Development of Malaria Parasites. Sturm A, Graewe S, Franke-Fayard B, Retzlaff S, Bolte S, Roppenser B, Aepfelbacher M, Janse C, Heussler V. Protist. 2009; 160(1):51-63.