Leiden Malaria Research Group (LMRG)

Algemene informatie over malaria

(General information malaria in Dutch)

Head of the group: Dr. Chris J. Janse
Principal investigators: Dr. C.J. Janse, Dr. B. Franke-Fayard, Dr. S.M. Khan

Main research themes:

• Developmental biology and genetics of malaria parasites
• Identification and analysis of drug and vaccine target proteins
• Analysis of parasite-host(cell) interactions
• Generation and analysis of genetically attenuated parasites

We use a malaria parasite of rodents, Plasmodium berghei, as a model for human malaria infections 
Rodent malaria parasites are practical model organisms for the experimental study of human malaria and are analogous to the malarias of man and other primates in most essential aspects of structure, physiology and life cycle.

• News about the research
• Background information about the disease malaria (mainly in Dutch)
• Information about the research lines and publications of the LMRG
• Protocols and databases from the LMRG are available on a password protected 'SharePoint' environment
• Standard plasmids for genetic modification and transgenic parasite lines from the LMRG are availble from Malaria Research and Reference Reagent Resource Center (MR4).

The Leiden Malaria Research Group provides a database containing information on genetically modified rodent parasite lines generated by many labs worldwide: see Pberghei.eu.